Fry, Leela, Bender, and Professor Farnsworth's clone/ward Cubert take an intergalactic trip, and when they return to Earth, they find the planet uninhabited. First, our merry band of messengers must fight off alien invaders bent on claiming the planet as their own. Then they must go in search of their missing colleagues as well as billions of citizens from Planet Earth. And before long the intrepid crew quite literally goes to Hell and back again. Will the world ever get back to normal, or is everyone totally boned?